Endocrine Abstracts

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease characterized by excessive matrix deposition that disrupts the normal alveolar architecture and lung physiology. Glucagon-like peptide 1 (GLP1) is a gut-produced hormone with insulinotropic effects. GLP1 receptor is expressed in the lung where it is implicated in the synthesis of the protein (SPs) and lipid fractions of the surfactant. We have previously shown that the GLP1 receptor agonist, l...

Aim: Gastric bypass surgery improves glycaemic control, but the underlying mechanisms including potential changes in adipoinsular axis are incompletely understood. The aim of this study was to investigate potentially causal or associated alterations in gene expression of adipokines, myokines, and hormones in the subcutaneous and visceral adipose tissue of diabetic and non-diabetic obese subjects before and after gastric bypass.Material and methods: Biops...

Background: Acromegaly most commonly results from an excess production of GH and secondary increase in IGF1. More than 95% of the time from the pituitary gland, but the source of excess GH secretion may not necessarily be pituitary in origin. Ectopic acromegaly may arise due to neuroendocrine tumors by production of GHRH and in <0.5% of the cases from ectopic pituitary remnants in the sphenoid sinus.Clinical case: We present a case of a 37 years old ...

Introduction: Data demonstrating antiproliferative effects of somatostatin analogs (SSAs) in enteropancreatic NETs are limited; only one prospective trial so far has shown this for patients with midgut tumors and low hepatic tumor load (HTL). CLARINET is the first large phase 3, randomized, placebo-controlled trial evaluating such effects for the SSA lanreotide in patients with non-functioning enteropancreatic NETs.Methods: Patients who had well/moderate...

Introduction: Isolated ACTH deficiency (IAD) is a rare entity characterized by secondary adrenal insufficiency with low levels of serum cortisol, decreased production of ACTH, adequate secretion of other pituitary hormones and normal pituitary structure on radioimaging. Due to the rarity of its occurrence the prevalence of IAD as a cause of secondary adrenal insufficiency has not been determined. To our knowledge 200 cases are described in the literature. Impairment of GH secr...

Hyperfunctional nodules of the thyroid are rarely associated with thyroid cancer, for these reason are rarely biopsied. Although multiple theories have being proposed, the relationship is still uncertain. After performing a MEDLINE literature search, we found in multiple retrospectives analysis, that patients with hyperthyroidism with hyperfunctional nodules have an estimated of 0.3–16.3% prevalence of malignancy. In our study forty-eight hyperthyroid cases were prospecti...

Context: Adrenal incidentalomas (AI) can be found in 3–10% of the general population. The vast majority of them (70%) represents nonfunctioning adrenal incidentalomas (NFAI). Although several comorbidities have been studied in patients with autonomous cortisol secretion (ACS) there are limited data for those with NFAI.Aim: To study metabolic disorders frequency in patients with AI and especially NFAI.Design: Retrospective stu...

Background: Patients with pituitary tumour live with life-long consequences of their disease. The first year after pituitary surgery represents a time period of symptoms, fear of tumour recurrence, existential concerns as well as extensive medical evaluations and decisions about hormone replacement. To increase wellbeing, a person-centred care practice up to 1 year after pituitary surgery covering self-management support, accessibility and continuity has been implemented and a...

Introduction: The prevalence and comorbidities of NAFLD in CD are unknown. There is only one study wich set the prevalence of NAFLD by CT images in 20%1.Objectives: Describe the prevalence of NAFLD and fibrosis in CD and analize predictive biomarkers of NAFLDMethods: Transversal descriptive study. 31 patients with CD; 11 active, 20 cured. Women 24 (77%), men 7 (23%). 54 years mean age. NAFLD was valorated by Hepatic Stea...

Purpose: Although quality of life (QoL) is improved in patients with acromegaly after disease control, QoL correlates only weakly with traditional biomarkers. Our objective is to investigate a potential relation between the new serum biomarker soluble Klotho (sKlotho), GH and insulin-like growth factor 1 (IGF-1) levels and QoL.Methods: In this prospective cohort study, we investigated 54 acromegaly patients biochemically well-controlled on combination tr...